"The individuals concerned and their means of transport were clearly marked with a distinctive emblem conferring the protection of the Geneva Conventions [on the conduct of warfare]," continued the same statement.
'Deeply shocked'
One of the paramedics was killed on the spot when Israeli Defense Force munitions suddenly hit the area, it said.
The other died of his injuries a few hours later.
The ICRC "deplores" the deaths and "is deeply shocked and saddened by this event," the statement said.
It noted that the Palestinian Red Crescent is a member of the international Red Cross movement.
"Under international humanitarian law, its medical personnel and means of transport must be protected and respected in all circumstances," the ICRC said.
The incident occurred during an Israeli offensive against Palestinian rocket squads.